Tramadol Gruenenthal GmbH’s trade name for tramadol hydrochloride, a synthetic opioid, an analog of codeine. It is an analgesic that acts through the central nervous system and one needs to take it to get relief from moderate to severe pain. It is used for a variety of conditions and is of particular use for fibromyalgia and restless leg syndrome. The doctor prescribes Tramadol when need to get constant relief from chronic pain. The drug has a high potential for abuse and the reason for this is euphoria. It is also noradrenergic and serotonergic. Before you buy tramadol overnight we recommend you to know some quick details about this drug.
How does Tramadol work?
Tramadol supposes to produce its analgesic effect by inhibiting the reuptake of norepinephrine and stimulating the release of serotonin. In addition, it has an antagonist for a wide range of neuroreceptors. It is also a mild agonist of the µ-opioid receptors. It also has an additional non-opioid effect although these are still a mystery. Tramadol is a 5HT2C antagonist and it is thought that this could be involved in the effectiveness of the drug in relieving symptoms of depression and obsessive-compulsive symptoms in patients with neurological diseases involving pain. Tramadol is more powerful in comparison to codeine when it comes to relieving chronic pain. Coming to hydrocodone then it is slightly less effective.
What does it look like?
Tramadol is available in a wide number of forms, the best and famous is a 50 mg tablet made by several manufacturers. Typically these are round and in most cases are white. You can buy it in a compound formulation with Acetaminophen as Ultracet, which contains 325 mg of Acetaminophen and 37.5 mg of tramadol. You can also buy as effervescent tablets and powders, extended release tablets, capsules, and suppositories. Preparations for hospital use include sterile ampoules of the solution, ultra-pure injection solutions for spinal injections, and in special solutions, sometimes in compounds with other analgesics for patient-controlled pain pumps.
Dosage and administration of Tramadol
The usual recommended starting dosage of tramadol is 25 mg, once daily, taken in the morning. This can be further increased by 25 mg up to 25 mg four times a day. The maximum dosage that should be reached is 400 mg a day in four to six doses. For rapid pain relief, a starting dose of 100 mg four times a day is enough, but this risk increase side effects. Patients with kidney problems should take no more than 100 mg every twelve hours and those with cirrhosis of the liver should take no more than 50 mg every twelve hours. The dosage needs to reduce and limited to a maximum of 300 mg a day in people over 65 years. You can take this medication with or without food.
Common adverse effects of Tramadol
Tramadol can occasionally cause an allergic reaction which may include hives, itching or wheezing. The most common side effects are constipation, nausea, vertigo, drowsiness, headache, vomiting or agitation. Less common are itching, indigestion, dry mouth, euphoria, contraction in pupils, loss of appetite or urinary retention.
Serious adverse effects
If you buy tramadol without prescription then be ready for some serious consequences.
Serious side effects of Tramadol occur rarely but may include seizures, serotonin syndrome consisting of confusion or a rapid heart rate or nausea, diarrhea, hallucinations, jumpy reflexes, fever, rapid changes in blood pressure, shivering, sweating, agitation or slow or irregular breathing.